I have a USB-C version that I setup with my MacBook. All of the services that use them seem to also support 2FA via “Google Authenticator” (which means you can use that or any compatible app, such as Authy or 1Password.) Most of the time I just use my 2FA codes via 1Password rather than my Yubikey.
The only PITA is that Google always defaults to looking for the Yubikey and takes a full minute or two to timeout and ask if you want to use another method. Minor annoyance, but worth noting.
Pro 1Password Tip
You can setup 1Password to keep your 2FA codes, but where do you store the 2FA code for your 1Password.com account?
(Besides using a Yubikey, of course.)
Answer: Authy! That way if anyone manages to figure out your Master Password, they’ll still need to access your Authy account before they can get into your 1Password information.