Depends on your ultimate goals and how much time and money you want to spend on a setup.
If DEVONthink had only one use-case, though, it’d be this. It has tools for managing groups (of PDFs), read/unread state, flagging, tags, labelling, full-text PDF search, built in OCR (in the Pro version), all the classic annotation tools, the ability to make a written annotation file linked to a reading, annotation extraction abilities, automatic summarization abilities, it can add and search on metadata fields for your readings, and more.
It’s expensive, it doesn’t handle image annotations like Highlights and a few other PDF editors, and it has a learning curve proportionate to the feature list above.
Note that it’s 25% off this weekend. (No, they don’t pay me!)