I’ve been running Ghostery for years in MacOS Safari (and Firefox) without issue (that I have noticed). It also autofills cookie consents which is quite satisfying. On iOS (and iPadOS) I run a combo of Purify and AdGuard Pro. I can’t remember why I use both, I have done for many years. I guess I got enthusiastic during a privacy spree. I rarely have trouble with them so they don’t conflict, and I don’t see ads in emails which may or may not be related (it came up in another conversation on here and I realised I’ve not seen email ads on my phone for years, I don’t know why but I’m not complaining!).