I’ve owned an Ergodox EZ, the precursor to this keyboard, for the last three years. It’s a fantastic keyboard if you deal with RSI-like issues while typing. The design lets you position it wider, closer together, tented, or otherwise to put your hands in a different position to relieve strain.
On the ortholinear layout, it takes a little while to get used to at first, but after that you don’t even think about it. I have no issues switching between this and other “normal” keyboards. It took three weeks to feel comfortable using it.
It makes more sense in regard to where you reach with your fingers. I find myself going shorter distances for the keys, which means I don’t strain as much.
That all being said, this will not solve RSI issues for you. It will give you options to ease strain, which helps different muscle groups recover. Posture and taking breaks will help more than this keyboard will. But if you’re looking for a nice typing experience that can aid in strain relief, the Ergodox is nice. I’d imagine the Moonlander will be as well.