I recently switched from Lightroom to DXO for raw conversion. The results I get with DXO are substantially better than those from using Lightroom, or, in the case of high ISO images, better than Lightroom, Lightroom + its built-in noise reduction tool, or Lightroom + Topaz AI Denoise.
I use a lot of tools in various combinations to process photos: Lightroom, Photoshop, DXO Photolab, and the Topaz AI suite (Denoise, Sharpen, and Gigpixel), depending on the image and what I want to do to it. But I always start with DXO for raw conversion and use Lightroom to manage my catalogue.
If you like working in Lightroom, a good option is to use DXO PureRAW2 for raw conversion.
DXO and Topaz both offer free 30 day trials for all of the products in their suites, so it’s possible to test them in conjunction with your current workflow.
One thing to keep in mind is the output format. With the Topaz suite in particular, processing will result in a DNG that may or may not allow you to work with Lightroom’s Adobe and camera-specific color rendering profiles. In some cases, the output is limited to a TIFF file. I’ve also found that when you use these tools in you workflow can make a big difference in the results. (And the order the developers suggest isn’t always the best one.)
An aside: If I had gotten DXO first, I might not have added the Topaz tools into the mix. I still use them in certain circumstances, and I’m glad they’re in my toolbox, but if I had to choose, I’d go with DXO. I’m giving Capture One a try at the moment; I’m not sure that its raw conversion is so much better than DXO’s that I’d be willing to shell out for it just for that, but some of the editing tools look interesting.
PS - I should have mentioned this at the outset: both DXO Photolab / PureRAW2 and the Topaz suite of tools are straightforward to incorporate into a Lightroom workflow. Capture One, less so.