Greetings~
@TimInHouston, I found my sweet spot with MailMate + SpamSieve, this combo helps me power through communications and handle spam on my own conditions without the necessary monthly subscription to sanebox.
MailMate is pretty much eMail for Power Users, its filter capabilities is extensive and full featured. Think of Apple Mail on steroids and everything you would wish it to be.
SpamSieve, advanced spam filtering and control over what gets considered spam, there is some training required (good reference) but the rewards are well worth it.
Hope this helps.
Cheers,
Dan