I start DT with the Mac.
I use a couple of rather large databases, and it took several minutes for DT to finish the start sequence, so I have it running, to be available all the time.
The amount of memory, DT is using, depends, as far as I understand, on the size of your database(s).
I have it currently running, with 3 open databases (+Global Inbox) with a total of more than 500.000 Objects in the databases, and a total of more than 500GB size.
Beside that I have a Mail-Program with a couple of thousand mails, Safari with (unfortunately!) several hundred open tabs, and some other apps running, on a 64GB 2017 iMac, without any severe problems.
Thanks for the reply! My overhead is much smaller. I never have more than 5-6 tabs open at one time in Safari I have three DT databases open with ~30K files total so not nearly as large as yours. Also, in addition to DT I only have Mail, Calendar, Notes, and Ulysses running and three utilizes, 1PW, Moom, and Bartender.
Based on your experience, you’d recommend I just keep DT open, correct?
Devonthink has surprisingly low resource usage.
In fact, comparing resource usage and features, Slack (an electron app) should be performing all my work for me, sorting out my love life, and probably start fixing all my neighbours problems as well.