I have Ad Guard which comes with the SetApp subscription. I loved it but when I downloaded Monterey, well a rep at Apple Care finally figured out that was causing interference, probably with the privacy settings . I was having a heckuva time getting on the Internet. I am hesitant to reactivate it because it was a royal pain. I’m going to see if they cannot iron out the details before reactivating it.
I use pi-hole to block ads on my entire network. I set that as DNS and the amount of ads I see is reduced drastically. When I’m out I have wireguard on and tunnel into my home network and through the pi-hole to the internet.
This works perfectly as an addition to using ad blockers, or maybe instead of, as I’ve sometimes had issues with sites not functioning well or being inaccessible when using an adblocker locally