AirPlay Interfering with Audio in Mac Pro 4,1?

For the past few months, I’ve been having issues with my USB 2.0-powered Duet 2 audio interface. After a couple of minutes of use, the Duet will begin cycling on and off, causing the audio to cut out and my speakers to pop.

After having looked at a Systems Report of my Mac 4,1, Apogee’s tech support noticed that AirPlay is interfering with the Duet’s connection. They’re not yet sure, however, how exactly this is working, and what specifically might be causing this interference.

Anyone have any idea how and why AirPlay would interfere with the functioning of an audio interface?

Mac Pro 4,1 (early 2009) running 10.11.6