Curious… No idea if this is possible. Could there be a way using applescript to hunt for the unsubscribe links in the mail app and ‘click’ it when it finds it?
Looking for a keyboard shortcut to just click unsubscribe automatically. I do have a smart folder looking for those emails with that word but figured this would be a cool next automated step!
Not necessarily a good idea. I get several spam emails a week asking me to confirm an unsubscribe from sites I’ve never subscribed to. It’s just a trick to see if they’ve hit a live email address.
True - I just mean if I know it is an email I want to unsubscribe from - without having to search for it with a keystroke it would be awesome to do it rather than hunting for where that link is in the email, etc. I would be the deciding factor (and I realize there is a lot of spam with confirming emails as you mentioned). 
I have not seen this happen on macos in my experience…