I used Newton until they pulled the plug. Not going back as I don’t consider them reliable now.
I use MailMate and like the markdown editing, commands to send things to DEVONthink, OmniFocus, etc. I also tag things, and have the tags in the menu bar, making it easy. I is SpamSieve to take care of the spam. All in all a good investment in the two of them.
I use AirMail on iOS.
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