I am on an Alice! Probably for over a year now given the date on my other post. Doesn’t time fly!
TL;DR Alice might be good for you if you have hand issues. At the very least, it probably won’t make things any worse than a regular keyboard would.
I went to an Alice originally because I wasn’t convinced I’d be happy with a full split. My main concern with a full split is that you can’t fix how far apart the two halves are. I touch type and I think the two halves varying in distance regularly as I move things on my desk is going to make typing annoying. (I’ve not tested it to be sure, but I’m guessing it’s like when you try a keyboard with a slightly different layout and type gibberish until your hands find the right place to sit.)
Now I’ve tried an Alice I don’t think I will go back to a regular keyboard, and I think I’ve found keyboard nirvana.
I built my own custom keyboard, but the suggested layout is the same as the Keychron one (fn was in the same place on mine too, I see @brookter querying that but I think it might be standard?). Anyway I re-mapped the left thumb key next to the space bar to be the option key. I trigger Alfred and various hotkeys with OPT so it made sense for me. (I’m not sure I’d ever re-map shift, cmd, etc. My fingers wouldn’t like the change!) I also re-mapped the 3 keys on the right which I think are delete, page up and page down on a standard Alice layout. I have little need for those and I needed to appease the little demon on my shoulder that wants a Stream Deck, so I mapped them for a couple of apps I use a lot. Turns out this is very useful. If anything it’s a shame an Alice layout doesn’t have more obsolete keys I can re-map to useful things!
My keyboard has quite a good incline across the two halves, and I have the board tilted on risers. I don’t have rsi but I get wrist and finger pain (muscular not joint). I don’t think the angle and tilt of the board has made much difference to my hands (I think angle might help with neck and shoulder pain if you have that though?), but the key layout is definitely more comfortable for me. I can feel the difference whenever I switch back to an Apple keyboard and have to straighten my hands.
Regarding switching: I’ve not noticed any “lag time” in my brain. My hands know if I’m at my Alice keyboard or a regular keyboard.
Alice keyboards are annoying if you are typing one-handed, e.g. you’re holding a drink and typing (tut tut) / you’re on the phone and trying to pull something up quickly / you’ve broken your arm. If you type one-handed a lot you should ask yourself whether the Alice is a good idea (you should also ask yourself why you’re doing it a lot! Put your drink down, get a headset, or if it’s a permanent issue explore one-handed keyboard set-ups instead!).
I can’t think of anything else I would’ve liked to know beforehand, but ask if you have any questions!