I do not think that this is a software/driver issue.
This might be related to the hardware.
First of all, as you already have done, cleaning the scanner can help. If everything already is being clean, the mainboard, connections or the lamp or something else might have issues or could be defective.
According to this owner, his ancient S300 had the same error.
It apparently had issues with its lamp. He dismantled the scanner, disconnected cables and connected them again. It resolved the issue. It surely is nothing for the faint-hearted (and nothing for me).
A different option would be to get the scanner checked out by a professional, which of course could be expensive and I am not sure, if it makes sense given the product’s age. Then again, it might be worth trying…
What would I do? To be honest, I would consider buying a new scanner. Fujitsu’s current lineup can be found at
With their latest revival of ScanSnap Manager, they might still be a good option.
But it is a complicated topic.