I use a combination of wired, wireless, and powerline. Our house has three levels (four if you include the garage), so wireless is difficult even with mesh. I have a wired backbone that goes to each floor of the house (not including garage). It mostly goes through different levels of crawlspace as you go down the hill just because that was easiest for me to install on my own. My primary home use Mac, Synology NAS, and always-on Mini all use wired connections.
I’ve never been really happy with our wireless. We currently use an Orbi mesh with the main router attached to the wired backbone. The mesh signal will not get down to the lower level, even with satellites placed in the closest proximity I can get, so for that level the wired backbone transfers to a couple of Powerline adapters with built-in wireless (I can’t even get a reliable wireless signal from room to room on that level).
We’re in earthquake country so I suspect that all the plywood shear walls significantly hamper the wireless signal. Devices connected directly to the wired portion have great internet speed of about 450 Mbps down (as advertised by Comcast) and 11 Mbps up (a tad higher than advertised); but unless a wireless device is within a few feet of the Orbi router, and with nothing physically between router and device, the connection speed plummets to as low as 30 Mbps or 40 Mbps down and as low as 1 Mbps up – horrible. Barrier free signal between Orbi satellite and device is a little better, but it still frequently gets down below 100 Mbps and can give me a blocky signal on AppleTV (which is about 20 feet away from a satellite with no barriers).
It’s a lot more complicated than I had ever thought we’d need, but it works reliably now, if not at the speed I’d like to see on the wireless end of things. Time Machine to the Synology via wireless is just painful. I’m considering adding a couple more powerline adapters for high bandwidth devices like AppleTV; maybe even dumping the mesh in favor of powerline wireless access points.