Having just finished Taking Smart Notes with DEVONthink, I think I’m going to use DEVONthink. The book really gave me a new perspective, and showed me the capabilities of DT. A bonus is the interoperability with writing programs such as Scrivener, iAWriter, etc., and reference managers such as Bookends. Everything is local, there’s rudimentary mobile support with DEVONthink to Go, scripting is available, - it seems the natural choice.